Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Dantrolene, Sodium Salt
A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.
MilliporeSigma™ Calbiochem™ Deltamethrin
Synthetic type II pyrethroid. Potent inhibitor of calcineurin. Causes an increase in neurotransmitter release at synapses, and increases intrasynaptosomal Ca2+ levels.
MilliporeSigma™ Calbiochem™ STAT5 Inhibitor II, IQDMA
The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.
MilliporeSigma™ Calbiochem™ MK-886
A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO pathway activation by inhibiting FLAP, rather than 5-LO, activity.
MilliporeSigma™ Calbiochem™ Wnt Synergist, QS11
A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).
MilliporeSigma™ Calbiochem™ D-erythro-Sphingosine, N,N-Dimethyl-
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 μM) and stimulates Src kinase activity.
MilliporeSigma™ Calbiochem™ InSolution™ Cyclopamine, V. californicum
The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ BCL6 Inhibitor, 79-6
The BCL6 Inhibitor, 79-6 controls the biological activity of BCL6. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ GGACK
An irreversible inhibitor of urokinase (IC50 1 μM) and Factor Xa.
MilliporeSigma™ Calbiochem™ InSolution™ PD 98059
InSolution™ PD 98059, CAS 167869-21-8, is a 5mg/mL solution in DMSO. A a cell-permeable, selective and reversible inhibitor of MAP Kinase Kinase (MEK).
MilliporeSigma™ Calbiochem™ PKR Inhibitor, Negative Control
The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Phosphatase Inhibitor Cocktail Set IV
A cocktail of three phosphatase inhibitors for the inhibition of both serine/threonine and alkaline phosphatases.
MilliporeSigma™ Calbiochem™ Phosphatase Inhibitor Cocktail Set II
A cocktail of five phosphatase inhibitors for the inhibition of acid and alkaline phosphatases as well as protein tyrosine phosphatases (PTPs). Suitable for use with cell lysates and tissue extracts.
MilliporeSigma™ Calbiochem™ Wnt Agonist
The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ G-Protein βγ Binding Peptide, mSIRK(L9A)
A cell-permeable, single point mutated (Leu9 to Ala), N-myristoylated G-protein βγ Binding Peptide (mSIRK).